CHM401A - Organic Chemistry I
Prerequisites:
3-0-0-9
Course Contents
Stereochemistry, Dynamic stereochemistry, Mechanistic and Stereo chemical aspects, Reactive Intermediates: Carbenes, Nitrenes, Radicals, Carbocations.
Mechanistic and Stereochemical Aspects of: (10) Baeyer-Villiger, Claisen (including Johnson-Claisen, Ireland-Claisen, Eschenomser, Overman modifications) Cope, and oxy-Cope, Wittig rearrangements (both 1,2 and 2,3 Wittig rearrangements); ene and metalloene reactions; (2+2), (3+2) and (4+2) cycloadditions; Barton reaction.
Organometallic Chemistry: (5) Mechanism and stereochemistry of various reactions. Palladium based reactions such as Heck, Stille, Suzuki, Sonogashira, Buchwald-Hartwig couplings; Tsuji-Trost C-C bond formations; Ni and Sn catlysed reactions.
Enzymatic Reactions: (3) Mecahnistic and stereochemical aspects of hydrolases (including esterases and lipases), oxido-reductases.
Green Chemistry: Concepts and applications (3)
Classification and Structures of some natural products such as terpenoids, steroids, alkaloids and prostaglandins (5)
Topics
Current Course Information
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Books and References
March, J., Advanced Organic Chemistry, 4th ed, 1999.
Nasipuri, D., Stereochemistry of Organic Compounds, 2nd ed., 1995.
Solomons, T. W. G., Organic Chemistry 6th ed, 1996.
Sykes, Peter, A guide book to Mechanism in Organic Chemistry.
R. Bruckner, Advanced Organic Chemistry, 2002
R. Bruckner, Organic Mechanisms, 2010
M. B. Smith, Organic Synthesis, 3rd Ed. 2010
Clayden, Greeves, Warren, and Wothers, Organic Chemistry, 1st ed, 2001