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Jayandharan Giridhara Rao
PhD (Christian Medical College, Vellore)
Professor, Department of Biological Sciences & Bioengineering (BSBE)
Research Interest
Our research program is focused on developing a state-of-art molecular medicine platform to address the unmet clinical needs for several monogenic human diseases (haemophilia, retinal degeneration) and cancers (hepatocellular carcinoma, leukaemia). To achieve this, we interface at the basic biology of a virus (AAV) and its translational science; utilizing a variety of molecular, cellular and preclinical models.
Office
Department of Biological Sciences and Bioengineering
Indian Institute of Technology
Kanpur 208 016 (U.P)
Specialization
Gene therapy, Human molecular genetics
Education
Post-doctoral Fellow- 2007-2009, Powell Gene Therapy Center, University of Florida, Gainesville, USA.
PhD [Biomedical sciences/ Molecular Biology]-2008, Christian Medical College, Vellore, India.
Teaching Area
Microbiology and Immunology
Cellular & Molecular Biology
Biochemistry and Biochemical Engineering
Selected Publications
Publications in 2019Mary B, Maurya S, Kumar M, Bammidi S, Kumar V, Jayandharan GR*. Molecular engineering of Adeno-associated virus capsid improves its therapeutic gene transfer in murine models of hemophilia and retinal degeneration. Molecular Pharmaceutics 2019, 16:4738-4750.
Maurya S, Mary B, Jayandharan GR*. Rational engineering and evaluation of Neddylation and SUMOylation site modified AAV vectors in murine models of hemophilia B and Leber congenital amarousis. Hum Gene Ther 2019, doi:10.1089/hum.2019.164.
Khan N, Bammidi, S, Jayandharan, GR*. A CD33 antigen targeted AAV6 vector expressing an inducible caspase-9 suicide gene is therapeutic in a xenotransplantation model of acute myeloid leukemia. Bioconjugate Chem. 2019, 30:2404-2416.
Mary B, Maurya S, Arumugam S, Kumar V, Jayandharan GR. Post-translational modifications in capsid proteins of recombinant adeno-associated virus (AAV) 1-rh10 serotypes. FEBS J. 2019, 286:4964-4981.
Awards & Fellowships
Awards2017-22 Senior Fellowship, Wellcome Trust DBT India Alliance
Awards2015 B.M. Birla Science Prize in Biology
Awards2014 Young scientist award, YIM-MIT Boston, USA
Awards2014-17 Senior Innovative Young Biotechnologist award, Department of Biotechnology, Government of India
Awards2012-17 Swarnajayanti Fellowship, Department of Science and Technology, Government of India
Awards2010-12 Bayer Hemophilia Early Career Investigator Award, Bayer Inc, USA
Keywords
Gene Therapy, Molecular Genetics
Professional Experience
Dec 2019- Present Professor, Department of Biological Sciences and Bioengineering, IIT-Kanpur
Oct 2014- Dec 2019 Associate Professor, Department of Biological Sciences and Bioengineering, IIT-Kanpur