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Asima Pradhan
PhD (City University of New York)
Professor, Department of Physics
Research Interest
My research interests have been in the area of Biophotonics, attempting to understand tissue fluorescence and light scattering in human tissue environment and to evaluate its use for diagnosis of disease. Recent focus lies in the areas of Fluorescence Mueller matrix imaging and spectroscopy, attenuation free fluorescence based diagnostics which include development of automated device for clinical use, development of fluorescence and photoacoustic diffuse optical tomographic reconstruction algorithms, frequency domain tomography for tissue diagnosis and fluorescence lifetime imaging in the ultrafast regime. Future interests are to explore ways to improve such diagnostic capabilities in order take it towards the desired goal of noninvasive and early detection of disease, specifically cancer.
SL-111,BIO-PHOTONICS LAB,
SL-215, Center for Lasers and Photonics, Southern Block
Department of Physics
IIT Kanpur,
Kanpur 208016
Specialization
Biophotonics, Laser Spectroscopy, Optics, Biomedical imaging and spectroscopy
Education
PhD, Physics, City University of New York, Oct. 1991Thesis Title:Thesis Title:Fluorescence Spectroscopic Properties of Normal and Abnormal Biomedical MaterialsThesis Supervisor:R.R. Alfano
M.Sc., Delhi University, 1982
B.Sc., BJB College, Bhubaneswar,Orissa, 1980
Teaching Area
Optics
Principles of Lasers
Electromagnetic Theory
Biophotonics
Selected Publications
J. Jagtap, S. Chandel, N. Das, J. Soni, S. Chatterjee, A. Pradhan, and N. Ghosh. "Quantitative Mueller matrix fluorescence spectroscopy for precancer detection." Optics letters 39, no. 2 (2014): 243-246.
Yang Pu, Jaidip Jagtap, Asima Pradhan, and Robert R. Alfano. "Optical quantitative pathology of cervical intraepithelial neoplasia in human tissues using spatial frequency analysis." Journal of Biophotonics (2014).
Fluorescence spectra from cancerous and normal human breast and lung tissues, R. R. Alfano, G. C. Tang, A. Pradhan, W. Lam, D.S.J. Choy, E. Opher, IEEE J. Quantum Electron., QE-23 (10), 1806, 1987. Cited (344)
"Method for determining if tissue is malignant as opposed to nonmalignant using time - resolved fluorescence spectroscopy", R.R.Alfano, A.Pradhan, G.C.Tang, L.Wang, Y.Bundansky and B.B.Das; U.S Patent Number 5,348,018 awarded September 20, 1994 Cited (75)
Spectral properties of metastatic and nonmetastatic cells from different species, A.Pradhan, P.Pal, G. Durocher, L. Villeneuve, L. Gaboury, J. Photochem. Photobiol (Biol). 31, 101, (1995). Citation (103)
Recovery of turbidity free fluorescence from measured fluorescence an experimental approach, N.C. Biswal, Sharad Gupta, N. Ghosh and A. Pradhan, Optics Express, Vol.11, No. 24, pp. 3320-3331, Dec. 2003. Citation (38) (Also in Virtual Journal of Biological Physics Research)
Mueller decomposition images for cervical tissue: Potential for discriminating normal and dysplastic states, Prashant Shukla and Asima Pradhan, Optics Express, Vol. 17, 1600 (2009) Citation (13) (Also in Virtual Journal of Biological Physics Research)
Research Result
Fluorescence Mueller matrix spectroscopy has been utilized to understand fluorophore (collagen from stromal region)activity human cervical tissue sections effectively. A polarized fluorescence based automated device is being developed for clinical diagnostics of cervical precancers.
Research Group
Ph.D students:
1.Jaidip Jagtap
2.Seema Devi
3.Pankaj Singh
4.Bharat Lal Meena
5.Prabodh Kr. Pandey
6.Pavan Kumar
7. M. Zaffer
8.Gyan Ranjan SahooM.Sc. students:
1. Sanjeev Kumar
2. Yashu